This work is licensed under a Creative Commons Attribution 4.0 International License.
Temporin-1Sa [L2,9A;V6A]
General Information
DRACP ID DRACP00671
Peptide Name Temporin-1Sa [L2,9A;V6A]
Sequence FASGIAGMAGKLF
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | IC50>600µM | MTT assay | 72h | 1 |
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | Leukemia | IC50>60µM | MTT assay | 72h | 1 |
Hemolytic Activity Rat erythrocytes: 50% Hemolysis>200µM; Human erythrocytes: 50% Hemolysis >100µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C59H92N14O15S
Absent amino acids CDEHNPQRTVWY
Common amino acids AG
Mass 148376
Pl 9.7
Basic residues 1
Acidic residues 0
Hydrophobic residues 7
Net charge 1
Boman Index 1745
Hydrophobicity 117.69
Aliphatic Index 83.08
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28319176
Title Insight into the mechanism of action of temporin-SHa, a new broad-spectrum antiparasitic and antibacterial agent
Doi 10.1371/journal.pone.0174024
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.