Wollamide B [l3D-Phe(4Cl), V4I, N5D-Orn]

General Information


DRACP ID  DRACP00687

Peptide Name   Wollamide B [l3D-Phe(4Cl), V4I, N5D-Orn]

Sequence  WLxIxx

Sequence Length  6

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HepG2 Hepatoblastoma Blastoma IC50>100µM CellTiter-Glo assay 48h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  NCB: Trp1<--->x(6)

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  x(3)=D-4-Cl-Phe; x(5)=D-Orn; x(6)=D-Orn

Chiral  Mix



Physicochemical Information


Formula  C23H28N4O

Absent amino acids  ACDEFGHKMNPQRSTVY

Common amino acids  ILW

Mass  46587

Pl  6.11

Basic residues  0

Acidic residues  0

Hydrophobic residues  3

Net charge  0

Boman Index  1217

Hydrophobicity  123.33

Aliphatic Index  130

Half Life 
  /

Extinction Coefficient cystines  5500

Absorbance 280nm  1100

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28423019

Title  Design, synthesis and structure-activity relationship study of wollamide B; a new potential anti TB agent

Doi 10.1371/journal.pone.0176088

Year  2017

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.