This work is licensed under a Creative Commons Attribution 4.0 International License.
Wollamide B [l3D-Phe(4Cl)]
General Information
DRACP ID DRACP00688
Peptide Name Wollamide B [l3D-Phe(4Cl)]
Sequence WLxVNx
Sequence Length 6
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | IC50=60µM | CellTiter-Glo assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond NCB: Trp1<--->x(6)
N-terminal Modification Free
C-terminal Modification Free
Other Modification x(3)=D-4-Cl-Phe; x(6)=D-Orn
Chiral Mix
Physicochemical Information
Formula C26H34N6O4
Absent amino acids ACDEFGHIKMPQRSTY
Common amino acids LNVW
Mass 58396
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 3
Net charge 0
Boman Index 465
Hydrophobicity 60
Aliphatic Index 113.33
Half Life
/
Extinction Coefficient cystines 5500
Absorbance 280nm 1100
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28423019
Title Design, synthesis and structure-activity relationship study of wollamide B; a new potential anti TB agent
Doi 10.1371/journal.pone.0176088
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.