This work is licensed under a Creative Commons Attribution 4.0 International License.
Temporin-1Tb [L1F,N7L,L9del]-K
General Information
DRACP ID DRACP00694
Peptide Name Temporin-1Tb [L1F,N7L,L9del]-K
Sequence FLPIVGLLKSLLK
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=59µM | PI flow cytometric assay | 24h | 1 |
Hemolytic Activity Horse erythrocytes: <10% Hemolysis=48µM
Normal (non-cancerous) Cytotoxicity PBMC: IC50=52µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C72H125N15O15
Absent amino acids ACDEHMNQRTWY
Common amino acids L
Mass 165511
Pl 10.81
Basic residues 2
Acidic residues 0
Hydrophobic residues 8
Net charge 2
Boman Index 2298
Hydrophobicity 153.08
Aliphatic Index 202.31
Half Life
Mammalian:
Yeast:
E.coli:
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28443279
Title Analogs of the Frog-skin Antimicrobial Peptide Temporin 1Tb Exhibit a Wider Spectrum of Activity and a Stronger Antibiofilm Potential as Compared to the Parental Peptide
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.