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BP100 [Y10A]
General Information
DRACP ID DRACP00696
Peptide Name BP100 [Y10A]
Sequence KKLFKKILKAL
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=23.2±2.4µM | MTT assay | 48h | 1 |
| MCF-7/ADM | Invasive breast carcinoma of no special type | Carcinoma | IC50=21.4±2.7µM | MTT assay | 48h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL17 positive; Chronic myeloid leukemia | Leukemia | IC50=27.4±3.5µM | MTT assay | 48h | 1 |
| K562/ADM | Blast phase chronic myelogenous leukemia, BCR-ABL18 positive; Chronic myeloid leukemia | Leukemia | IC50=31.3±4.0µM | MTT assay | 48h | 1 |
Hemolytic Activity Rabbit erythrocytes: 4% Hemolysis=160µM
Normal (non-cancerous) Cytotoxicity GES-1: IC50=77.3±7.4µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C66H120N16O12
Absent amino acids CDEGHMNPQRSTVWY
Common amino acids K
Mass 150834
Pl 11.4
Basic residues 5
Acidic residues 0
Hydrophobic residues 6
Net charge 5
Boman Index -328
Hydrophobicity 9.09
Aliphatic Index 150.91
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28474125
Title Design, synthesis and biological evaluation of novel peptides as potential agents with anti-tumor and multidrug resistance-reversing activities
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.