BP100 [Y10E]

General Information


DRACP ID  DRACP00698

Peptide Name   BP100 [Y10E]

Sequence  KKLFKKILKEL

Sequence Length  11

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
MCF-7 Invasive breast carcinoma of no special type Carcinoma IC50=83.2±6.7µM MTT assay 48h 1
MCF-7/ADM Invasive breast carcinoma of no special type Carcinoma IC50=79.5±6.9µM MTT assay 48h 1
K562 Blast phase chronic myelogenous leukemia, BCR-ABL23 positive; Chronic myeloid leukemia Leukemia IC50=89.4±7.3µM MTT assay 48h 1
K562/ADM Blast phase chronic myelogenous leukemia, BCR-ABL24 positive; Chronic myeloid leukemia Leukemia IC50>100µM MTT assay 48h 1

Hemolytic Activity  Rabbit erythrocytes: 6.5% Hemolysis=160µM

Normal (non-cancerous) Cytotoxicity  GES-1: IC50>100µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00698

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C68H122N16O14

Absent amino acids  ACDGHMNPQRSTVWY

Common amino acids  K

Mass  156637

Pl  10.98

Basic residues  5

Acidic residues  1

Hydrophobic residues  5

Net charge  4

Boman Index  -1190

Hydrophobicity  -39.09

Aliphatic Index  141.82

Half Life 
  Mammalian: 1.3 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28474125

Title  Design, synthesis and biological evaluation of novel peptides as potential agents with anti-tumor and multidrug resistance-reversing activities

Doi 10.1007/s00726-017-2434-1

Year  2017

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.