This work is licensed under a Creative Commons Attribution 4.0 International License.
BP100 [Y10R]
General Information
DRACP ID DRACP00704
Peptide Name BP100 [Y10R]
Sequence KKLFKKILKRL
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=59.4±2.9µM | MTT assay | 48h | 1 |
| MCF-7/ADM | Invasive breast carcinoma of no special type | Carcinoma | IC50=57.3±4.5µM | MTT assay | 48h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL25 positive; Chronic myeloid leukemia | Leukemia | IC50=60.8±5.3µM | MTT assay | 48h | 1 |
| K562/ADM | Blast phase chronic myelogenous leukemia, BCR-ABL26 positive; Chronic myeloid leukemia | Leukemia | IC50=71.2±4.7µM | MTT assay | 48h | 1 |
Hemolytic Activity Rabbit erythrocytes: 5% Hemolysis=160µM
Normal (non-cancerous) Cytotoxicity GES-1: IC50>100µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C69H127N19O12
Absent amino acids ACDEGHMNPQSTVWY
Common amino acids K
Mass 159344
Pl 12.05
Basic residues 6
Acidic residues 0
Hydrophobic residues 5
Net charge 6
Boman Index -2001
Hydrophobicity -48.18
Aliphatic Index 141.82
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28474125
Title Design, synthesis and biological evaluation of novel peptides as potential agents with anti-tumor and multidrug resistance-reversing activities
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.