This work is licensed under a Creative Commons Attribution 4.0 International License.
BP100 [Y10T]
General Information
DRACP ID DRACP00705
Peptide Name BP100 [Y10T]
Sequence KKLFKKILKTL
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=36.9±4.0µM | MTT assay | 48h | 1 |
| MCF-7/ADM | Invasive breast carcinoma of no special type | Carcinoma | IC50=33.7±3.9µM | MTT assay | 48h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL21 positive; Chronic myeloid leukemia | Leukemia | IC50=32.2±2.2µM | MTT assay | 48h | 1 |
| K562/ADM | Blast phase chronic myelogenous leukemia, BCR-ABL22 positive; Chronic myeloid leukemia | Leukemia | IC50=39.5±3.7µM | MTT assay | 48h | 1 |
Hemolytic Activity Rabbit erythrocytes: 5% Hemolysis=160µM
Normal (non-cancerous) Cytotoxicity GES-1: IC50=82.8±9.2µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C67H122N16O13
Absent amino acids ACDEGHMNPQRSVWY
Common amino acids K
Mass 153836
Pl 11.4
Basic residues 5
Acidic residues 0
Hydrophobic residues 5
Net charge 5
Boman Index -766
Hydrophobicity -13.64
Aliphatic Index 141.82
Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28474125
Title Design, synthesis and biological evaluation of novel peptides as potential agents with anti-tumor and multidrug resistance-reversing activities
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.