Peptide Libraray

FR-15

General Information

DRACP ID DRACP00706

Peptide Name FR-15

Sequence FRRFFKWFRRFFKFF

Sequence Length 15

UniProt ID Not available

PubChem CID Not available

Origin AMP

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
MDA-MB-231	Breast adenocarcinoma	Carcinoma	IC50=3.15 μM	MTT assay	24h	1
HeLa	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	IC50=4.9 μM	MTT assay	24h	1
DLD-1	Colon adenocarcinoma	Carcinoma	IC50=6.7 μM	MTT assay	24h	1
Hep-G2	Hepatoblastoma; Hepatoblastoma	Blastoma	IC50=2.5 μM	MTT assay	24h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity Not available

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antimicrobial

Structure Information

PDB ID Not available

Predicted Structure DRACP00706

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral L

Physicochemical Information

Formula C119H156N30O16

Absent amino acids ACDEGHILMNPQSTVY

Common amino acids F

Mass 251259

Pl 12.98

Basic residues 6

Acidic residues 0

Hydrophobic residues 9

Net charge 6

Boman Index -4461

Hydrophobicity -28.67

Aliphatic Index 0

Half Life
Mammalian: 1.3 hour
Yeast: 3 min
E.coli: 2 min

Extinction Coefficient cystines 5500

Absorbance 280nm 392.86

Polar residues 0

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 28483698

Title Selective phenylalanine to proline substitution for improved antimicrobial and anticancer activities of peptides designed on phenylalanine heptad repeat

Doi 10.1016/j.actbio.2017.05.007

Year 2017

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available