FR4P

General Information


DRACP ID  DRACP00710

Peptide Name   FR4P

Sequence  FRRPFKWFRRFFKFF

Sequence Length  15

UniProt ID  Not available

PubChem CID  Not available

Origin  AMP

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
MDA-MB-231 Breast adenocarcinoma Carcinoma IC50=6.3 μM MTT assay 24h 1
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma IC50=7.7 μM MTT assay 24h 1
DLD-1 Colon adenocarcinoma Carcinoma IC50=9.4 μM MTT assay 24h 1
Hep-G2 Hepatoblastoma; Hepatoblastoma Blastoma IC50=2.5 μM MTT assay 24h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antimicrobial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00710

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C115H154N30O16

Absent amino acids  ACDEGHILMNQSTVY

Common amino acids  F

Mass  246253

Pl  12.98

Basic residues  6

Acidic residues  0

Hydrophobic residues  8

Net charge  6

Boman Index  -4759

Hydrophobicity  -58

Aliphatic Index  0

Half Life 
  Mammalian: 1.1 hour
  Yeast: 3 min
  E.coli: 2 min

Extinction Coefficient cystines  5500

Absorbance 280nm  392.86

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28483698

Title  Selective phenylalanine to proline substitution for improved antimicrobial and anticancer activities of peptides designed on phenylalanine heptad repeat

Doi 10.1016/j.actbio.2017.05.007

Year  2017

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.