This work is licensed under a Creative Commons Attribution 4.0 International License.
Sphistin (12-38)
General Information
DRACP ID DRACP00722
Peptide Name Sphistin (12-38)
Sequence KAKAKAVSRSARAGLQFPVGRIHRHLK
Sequence Length 27
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | Not active up to 100 µg/ml | MTS assay | 24h | 1 |
Hemolytic Activity Crab haemocytes: Not active up to 100 µg/ml
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C132H228N48O31
Absent amino acids CDEMNTWY
Common amino acids A
Mass 344751
Pl 12.99
Basic residues 10
Acidic residues 0
Hydrophobic residues 11
Net charge 10
Boman Index -6679
Hydrophobicity -56.3
Aliphatic Index 83.33
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28600196
Title A truncated Sph12-38 with potent antimicrobial activity showing resistance against bacterial challenge in Oryzias melastigma
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.