This work is licensed under a Creative Commons Attribution 4.0 International License.
Bombinin H-BO
General Information
DRACP ID DRACP00724
Peptide Name Bombinin H-BO
Sequence IIGPVLGLIGKALGGLL
Sequence Length 17
UniProt ID Not available
PubChem CID Not available
Origin skin secretion of Oriental fire-bellied toad, Bombina orientalis
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| SK-HEP-1 | Liver and intrahepatic bile duct epithelial neoplasm | Carcinoma | IC50=0.99 μM | MTT assay | 48h | 1 |
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | Blastoma | IC50=2.88 μM | MTT assay | 48h | 1 |
| Huh-7 | Adult hepatocellular carcinoma; Adult hepatocellular carcinoma | Carcinoma | IC50=1.81 μM | MTT assay | 48h | 1 |
Hemolytic Activity Human erythrocytes: Bombinin H-BO was found to lyse 38% of erythrocytes at concentration of 80.0 μm (128 mg/ml), and up to 85% at the concentration of 159.7 μm (256 mg/ml).
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C77H138N18O18
Absent amino acids CDEFHMNQRSTWY
Common amino acids GL
Mass 188966
Pl 9.7
Basic residues 1
Acidic residues 0
Hydrophobic residues 10
Net charge 1
Boman Index 4436
Hydrophobicity 182.35
Aliphatic Index 206.47
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28636781
Title Discovery of two bombinin peptides with antimicrobial and anticancer activities from the skin secretion of Oriental fire-bellied toad, Bombina orientalis
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.