Tachyplesin [C3,7,12,16Del]

General Information


DRACP ID  DRACP00726

Peptide Name   Tachyplesin [C3,7,12,16Del]

Sequence  KWFRVYRGIYRRR

Sequence Length  13

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
A549 Lung adenocarcinoma Carcinoma IC50=37180µM MTT assay Not available 1

Hemolytic Activity  Sheep erythrocytes: <1% Hemolysis=67µM

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00726

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C87H134N30O16

Absent amino acids  ACDEHLMNPQST

Common amino acids  R

Mass  207041

Pl  12.34

Basic residues  6

Acidic residues  0

Hydrophobic residues  4

Net charge  6

Boman Index  -6522

Hydrophobicity  -144.62

Aliphatic Index  52.31

Half Life 
  Mammalian:
  Yeast:
  E.coli:

Extinction Coefficient cystines  8480

Absorbance 280nm  706.67

Polar residues  3

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28641565

Title  D-Amino Acid Analogues of the Antimicrobial Peptide CDT Exhibit Anti- Cancer Properties in A549, a Human Lung Adenocarcinoma Cell Line

Doi 10.2174/0929866524666170621093647

Year  2017

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.