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Reverse D Tachyplesin [C3,7,12,16Del]
General Information
DRACP ID DRACP00727
Peptide Name Reverse D Tachyplesin [C3,7,12,16Del]
Sequence rrryiGryvrfwk
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=90.16µM | MTT assay | Not available | 1 |
Hemolytic Activity Sheep erythrocytes: <1% Hemolysis=8.4µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification k=D-Lys; w=D-Trp; f=D-Phe; r=D-Arg; v=D-Val; y=D-Tyr; i=D-Ile
Chiral Mix
Physicochemical Information
Formula C2H-19NO-10
Absent amino acids ACDEFHIKLMNPQRSTVWY
Common amino acids G
Mass 7309
Pl 6.11
Basic residues 0
Acidic residues 0
Hydrophobic residues 0
Net charge 0
Boman Index 94
Hydrophobicity -3.08
Aliphatic Index 0
Half Life
/
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28641565
Title D-Amino Acid Analogues of the Antimicrobial Peptide CDT Exhibit Anti- Cancer Properties in A549, a Human Lung Adenocarcinoma Cell Line
Doi 10.2174/0929866524666170621093647
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.