This work is licensed under a Creative Commons Attribution 4.0 International License.
Reverse Tachyplesin [C3,7,12,16Del]
General Information
DRACP ID DRACP00728
Peptide Name Reverse Tachyplesin [C3,7,12,16Del]
Sequence RRRYIGRYVRFWK
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | IC50=12100µM | MTT assay | Not available | 1 |
Hemolytic Activity Sheep erythrocytes: <1% Hemolysis=540µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C87H134N30O16
Absent amino acids ACDEHLMNPQST
Common amino acids R
Mass 207041
Pl 12.34
Basic residues 6
Acidic residues 0
Hydrophobic residues 4
Net charge 6
Boman Index -6522
Hydrophobicity -144.62
Aliphatic Index 52.31
Half Life
Mammalian:
Yeast:
E.coli:
Extinction Coefficient cystines 8480
Absorbance 280nm 706.67
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28641565
Title D-Amino Acid Analogues of the Antimicrobial Peptide CDT Exhibit Anti- Cancer Properties in A549, a Human Lung Adenocarcinoma Cell Line
Doi 10.2174/0929866524666170621093647
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.