This work is licensed under a Creative Commons Attribution 4.0 International License.
I-3
General Information
DRACP ID DRACP00729
Peptide Name I-3
Sequence LVKRFKKFFRKLKKSVLL
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin cationic host defense peptides
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=7.0±0.2 μM | MTT assay | 48h | 1 |
| MCF-7/Taxol | Invasive breast carcinoma of no special type | Carcinoma | IC50=10.3±0.3 μM | MTT assay | 48h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia | Leukemia | IC50=15.1±1.1 μM | MTT assay | 48h | 1 |
| K562/ADM | Blast phase chronic myelogenous leukemia; Chronic myeloid leukemia | Leukemia | IC50=12.9±0.3 μM | MTT assay | 48h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | IC50=6.5±0.3 μM | MTT assay | 48h | 1 |
Hemolytic Activity Rabbit red blood cells: modest hemolytic activity(as show in Fig.2)
Normal (non-cancerous) Cytotoxicity HUVEC: IC50=80.84±3.9 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C112H192N30O20
Absent amino acids ACDEGHIMNPQTWY
Common amino acids K
Mass 258234
Pl 12.58
Basic residues 8
Acidic residues 0
Hydrophobic residues 9
Net charge 8
Boman Index -2984
Hydrophobicity -6.67
Aliphatic Index 118.89
Half Life
Mammalian: 1 hour
Yeast: 2 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28664269
Title Pro-apoptotic cationic host defense peptides rich in lysine or arginine to reverse drug resistance by disrupting tumor cell membrane
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.