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MCoTI-II
General Information
DRACP ID DRACP00742
Peptide Name MCoTI-II
Sequence GGVCPKILKKCRRDSDCPGACICRGNGYCGSGSD
Sequence Length 34
UniProt ID Not available
PubChem CID Not available
Origin Momordica cochinchinensis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| U-937/GTB | Adult acute monocytic leukemia; Acute monoblastic/monocytic leukemia | Leukemia | IC50>>80µM | FMCA assay | 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys4<--->Cys21; Cys11<--->Cys23; Cys17<--->Cys29; NCB: Gly1<--->Asp34
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C138H231N47O46S6
Absent amino acids EFHMQTW
Common amino acids G
Mass 406582
Pl 8.38
Basic residues 6
Acidic residues 3
Hydrophobic residues 5
Net charge 3
Boman Index -6968
Hydrophobicity -44.41
Aliphatic Index 45.88
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1865
Absorbance 280nm 56.52
Polar residues 18
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28669767
Title Bactericidal activity of cyclotides where phosphatidylethanolamine-lipid selectivity determines antimicrobial spectra
Doi 10.1016/j.bbamem.2017.06.018
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.