This work is licensed under a Creative Commons Attribution 4.0 International License.
Kalata-B13
General Information
DRACP ID DRACP00747
Peptide Name Kalata-B13
Sequence GLPVCGETCFGGTCNTPGCACDPWPVCTRD
Sequence Length 30
UniProt ID Not available
PubChem CID Not available
Origin Oldenlandia affinis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| U-937/GTB | Adult acute monocytic leukemia; Acute monoblastic/monocytic leukemia | Leukemia | IC50=3.8µM | FMCA assay | 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys5<--->Cys19; Cys9<--->Cys21; Cys14<--->Cys27; NCB: Gly1<--->Asp30
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C126H191N35O42S6
Absent amino acids HIKMQSY
Common amino acids C
Mass 357794
Pl 3.88
Basic residues 1
Acidic residues 3
Hydrophobic residues 6
Net charge -2
Boman Index -2359
Hydrophobicity 4
Aliphatic Index 35.67
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5875
Absorbance 280nm 202.59
Polar residues 16
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28669767
Title Bactericidal activity of cyclotides where phosphatidylethanolamine-lipid selectivity determines antimicrobial spectra
Doi 10.1016/j.bbamem.2017.06.018
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.