Kalata B7 [Y15S]

General Information


DRACP ID  DRACP00748

Peptide Name   Kalata B7 [Y15S]

Sequence  GLPVCGETCTLGTCSTQGCTCSWPICKRN

Sequence Length  29

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
U-937/GTB Adult acute monocytic leukemia; Acute monoblastic/monocytic leukemia Leukemia IC50>>40µM FMCA assay 72h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial; Antifungal



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00748

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  Cys5<--->Cys19; Cys9<--->Cys21; Cys14<--->Cys26; NCB: Gly1<--->Asn29

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C122H200N36O41S6

Absent amino acids  ADFHMY

Common amino acids  C

Mass  351913

Pl  7.73

Basic residues  2

Acidic residues  1

Hydrophobic residues  5

Net charge  1

Boman Index  -2654

Hydrophobicity  5.52

Aliphatic Index  50.34

Half Life 
  Mammalian: 30 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  5875

Absorbance 280nm  209.82

Polar residues  18

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28669767

Title  Bactericidal activity of cyclotides where phosphatidylethanolamine-lipid selectivity determines antimicrobial spectra

Doi 10.1016/j.bbamem.2017.06.018

Year  2017

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.