This work is licensed under a Creative Commons Attribution 4.0 International License.
Cycloviolacin-O19
General Information
DRACP ID DRACP00749
Peptide Name Cycloviolacin-O19
Sequence GTLPCGESCVWIPCISSVVGCSCKSKVCYKD
Sequence Length 31
UniProt ID Not available
PubChem CID Not available
Origin Viola odorata
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| U-937/GTB | Adult acute monocytic leukemia; Acute monoblastic/monocytic leukemia | Leukemia | IC50=0.52µM | FMCA assay | 72h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys5<--->Cys21; Cys9<--->Cys23; Cys14<--->Cys28; NCB: Gly1<--->Asp31
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C138H223N35O43S6
Absent amino acids AFHMNQR
Common amino acids C
Mass 378815
Pl 7.73
Basic residues 3
Acidic residues 2
Hydrophobic residues 8
Net charge 1
Boman Index -814
Hydrophobicity 47.1
Aliphatic Index 75.16
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 7365
Absorbance 280nm 245.5
Polar residues 16
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28669767
Title Bactericidal activity of cyclotides where phosphatidylethanolamine-lipid selectivity determines antimicrobial spectra
Doi 10.1016/j.bbamem.2017.06.018
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.