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temporin-ITa
General Information
DRACP ID DRACP00752
Peptide Name temporin-ITa
Sequence FLGAIAQALTSLLGKL
Sequence Length 16
UniProt ID C0HL49
PubChem CID Not available
Origin skin secretions of the Italian stream frog Rana italica (Ranidae)
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MDA-MB-231 | Breast adenocarcinoma | Carcinoma | LC50=40 μM | CellTiter-Glo Lumines- cent Cell Viability assay | 24h | 1 |
| A549 | Lung adenocarcinoma | Carcinoma | LC50=45 μM | CellTiter-Glo Lumines- cent Cell Viability assay | 24h | 1 |
| HT-29 | Colon adenocarcinoma | Carcinoma | LC50=100 μM | CellTiter-Glo Lumines- cent Cell Viability assay | 24h | 1 |
Hemolytic Activity mouse erythrocytes: LC50=22 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification α-amidated residue at the C-terminus
Other Modification α-amidated residue at the C-terminus
Chiral L
Physicochemical Information
Formula C76H130N18O20
Absent amino acids CDEHMNPRVWY
Common amino acids L
Mass 188374
Pl 9.7
Basic residues 1
Acidic residues 0
Hydrophobic residues 10
Net charge 1
Boman Index 2275
Hydrophobicity 137.5
Aliphatic Index 165
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28699258
Title Cytotoxic peptides with insulin-releasing activities from skin secretions of the Italian stream frog Rana italica (Ranidae)
Doi 10.1002/psc.3025
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.