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Cyclic Gomesin [PYA1G, C2,6,11,15SeCys]
General Information
DRACP ID DRACP00763
Peptide Name Cyclic Gomesin [PYA1G, C2,6,11,15SeCys]
Sequence GXRRLXYKQRXVTYXRGR
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| CRL-1739 | Human gastric adenocarcinoma cells | Carcinoma | CC50=51.0±4.6µM | Resazurin assay | 24h | 1 |
| MM96L | Melanoma | Carcinoma | CC50=4.6±0.2µM | Resazurin assay | 24h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | CC50>64µM | Resazurin assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | CC50=37.5±3.3µM | Resazurin assay | 24h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL27 positive; Chronic myeloid leukemia | Leukemia | CC50=1.4±0.2µM | Resazurin assay | 24h | 1 |
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | CC50=38.5±4.8µM | Resazurin assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: 32.8±0.5% Hemolysis=64µM
Normal (non-cancerous) Cytotoxicity HFF-1: CC50=15.6±3.6µM; PBMC: CC50=15.5±0.8µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys2<--->Cys15; Cys6<--->Cys11; NCB: Gly1<--->Arg18
N-terminal Modification Free
C-terminal Modification Free
Other Modification X=Se-Cys
Chiral L
Physicochemical Information
Formula C78H125N31O15
Absent amino acids ACDEFHIMNPSW
Common amino acids R
Mass 248043
Pl 12.34
Basic residues 6
Acidic residues 0
Hydrophobic residues 2
Net charge 6
Boman Index -7770
Hydrophobicity -144.44
Aliphatic Index 37.78
Half Life
/
Extinction Coefficient cystines 2980
Absorbance 280nm 175.29
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28741926
Title Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties
Doi 10.1021/acschembio.7b00459
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.