This work is licensed under a Creative Commons Attribution 4.0 International License.
Cyclic Gomesin [PYA1K;C2,6,11,15SeCys;L5Y;K8R]
General Information
DRACP ID DRACP00767
Peptide Name Cyclic Gomesin [PYA1K;C2,6,11,15SeCys;L5Y;K8R]
Sequence KXRRYXYRQRXVTYXRGR
Sequence Length 18
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| CRL-1739 | Human gastric adenocarcinoma cells | Carcinoma | CC50=46.2±7.6µM | Resazurin assay | 24h | 1 |
| MM96L | Melanoma | Carcinoma | CC50=2.3±0.2µM | Resazurin assay | 24h | 1 |
| HeLa | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | CC50=36.2±2.8µM | Resazurin assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | CC50=29.0±3.7µM | Resazurin assay | 24h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL28 positive; Chronic myeloid leukemia | Leukemia | CC50=6.4±0.6µM | Resazurin assay | 24h | 1 |
| HL-60 | Adult acute myeloid leukemia; Acute myeloid leukemia | Leukemia | CC50=33.3±7.4µM | Resazurin assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: 20.9±3.1% Hemolysis=64µM
Normal (non-cancerous) Cytotoxicity HFF-1: CC50=30.8±2.0µM; PBMC: CC50=9.5±0.5µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys2<--->Cys15; Cys6<--->Cys11; NCB: Gly1<--->Arg18
N-terminal Modification Free
C-terminal Modification Free
Other Modification X=Se-Cys
Chiral L
Physicochemical Information
Formula C85H132N34O16
Absent amino acids ACDEFHILMNPSW
Common amino acids R
Mass 262957
Pl 12.22
Basic residues 7
Acidic residues 0
Hydrophobic residues 1
Net charge 7
Boman Index -9862
Hydrophobicity -195.56
Aliphatic Index 16.11
Half Life
/
Extinction Coefficient cystines 4470
Absorbance 280nm 262.94
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28741926
Title Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties
Doi 10.1021/acschembio.7b00459
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.