Gmred

General Information


DRACP ID  DRACP00769

Peptide Name   Gmred

Sequence  XCRRLCYKQRCVTYCRGR

Sequence Length  18

UniProt ID  Not available

PubChem CID  Not available

Origin  Redesigned Spider Peptide

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
CRL-1739 Gastric adenocarcinoma Carcinoma CC50>64 µM Resazurin assay 18-24h 1
MM96L Melanoma Carcinoma CC50=8.6 ± 0.8 µM Resazurin assay 18-24h 1
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma CC50>64 µM Resazurin assay 18-24h 1
K562 Blast phase chronic myelogenous leukemia, BCR-ABL1 positive; Chronic myeloid leukemia Leukemia CC50=2.7 ± 0.2 µM Resazurin assay 18-24h 1

Hemolytic Activity  Human red blood cells (hRBCs): hemolysis(%)=47.2±6.0 with 64 μM of peptide

Normal (non-cancerous) Cytotoxicity  HFF-1: CC50=58.2 ± 3.0 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antimicrobial



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  X=N-terminal pyroglutamic acid

Chiral  L



Physicochemical Information


Formula  C88H148N34O21S4

Absent amino acids  ADEFHIMNPSW

Common amino acids  R

Mass  256000

Pl  10.07

Basic residues  6

Acidic residues  0

Hydrophobic residues  2

Net charge  6

Boman Index  -7352

Hydrophobicity  -86.67

Aliphatic Index  37.78

Half Life 
  /

Extinction Coefficient cystines  3230

Absorbance 280nm  190

Polar residues  8

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28741926

Title  Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties

Doi 10.1021/acschembio.7b00459

Year  2017

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DBAASP ID  DBAASPS_5588

DRACP is developed by Dr.Zheng's team.