This work is licensed under a Creative Commons Attribution 4.0 International License.
As-CATH4
General Information
DRACP ID DRACP00770
Peptide Name As-CATH4
Sequence RRGLFKKLRRKIKKGFKKIFKRLPPVGVGVSIPLAGRR
Sequence Length 38
UniProt ID Not available
PubChem CID Not available
Origin Alligator sinensis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| BGC-823 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 26±0.9% Cell death=200µg/ml | MTT assay | 48h | 1 |
| BGC-823 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 58±1.5% Cell death=200µg/ml | MTT assay | 48h | 1 |
| BGC-823 | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 58±1.5% Cell death=200µg/ml | MTT assay | 48h | 1 |
Hemolytic Activity Human erythrocytes: 4±0.5% Hemolysis=200µg/ml
Normal (non-cancerous) Cytotoxicity CHO: 55±2.5% Cell death=200µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C205H359N67O40
Absent amino acids CDEHMNQTWY
Common amino acids K
Mass 506265
Pl 13.29
Basic residues 15
Acidic residues 0
Hydrophobic residues 14
Net charge 15
Boman Index -9023
Hydrophobicity -49.47
Aliphatic Index 97.37
Half Life
Mammalian:
Yeast:
E.coli:
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 6
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28798159
Title As-CATH1-6, novel cathelicidins with potent antimicrobial and immunomodulatory properties from Alligator sinensis, play pivotal roles in host antimicrobial immune responses
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.