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L-K6
General Information
DRACP ID DRACP00775
Peptide Name L-K6
Sequence IKKILSKIKKLLK
Sequence Length 13
UniProt ID Not available
PubChem CID Not available
Origin some cationic antimicrobial peptides
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=38 μM | MTT assay | 1h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=34 μM | MTT assay | 6h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=31 μM | MTT assay | 24h | 1 |
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=23 μM | MTT assay | 48h | 1 |
Hemolytic Activity Rabbit red blood cells: modest hemolytic activity(as show in Fig.2)
Normal (non-cancerous) Cytotoxicity HUVEC: IC50=65.88±4.5 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C75H145N19O15
Absent amino acids ACDEFGHMNPQRTVWY
Common amino acids K
Mass 176733
Pl 11.5
Basic residues 6
Acidic residues 0
Hydrophobic residues 6
Net charge 6
Boman Index -718
Hydrophobicity 5.38
Aliphatic Index 180
Half Life
Mammalian: 2.8 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28811617
Title Cell surface binding, uptaking and anticancer activity of L-K6, a lysine/leucine-rich peptide, on human breast cancer MCF-7 cells
Doi 10.1038/s41598-017-08963-2
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.