This work is licensed under a Creative Commons Attribution 4.0 International License.
Phylloseptin-PT
General Information
DRACP ID DRACP00777
Peptide Name Phylloseptin-PT
Sequence FLSLIPKIAGGIAALAKHL
Sequence Length 19
UniProt ID Not available
PubChem CID Not available
Origin Phyllomedusa baltea
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| NCI-H157 | Lung squamous cell carcinoma | Carcinoma | IC50=6.73µM | MTT assay | 24h | 1 |
Hemolytic Activity Horse erythrocytes: 10% Hemolysis=7.79µM; 50% Hemolysis=22.8µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C93H157N23O21
Absent amino acids CDEMNQRTVWY
Common amino acids AL
Mass 225469
Pl 10.81
Basic residues 3
Acidic residues 0
Hydrophobic residues 12
Net charge 3
Boman Index 2738
Hydrophobicity 128.95
Aliphatic Index 164.74
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28850103
Title Discovery of Phylloseptins that Defense against Gram-Positive Bacteria and Inhibit the Proliferation of the Non-Small Cell Lung Cancer Cell Line, from the Skin Secretions of Phyllomedusa Frogs
Year 201710.1007/s00726-017-2509-z
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.