Ilamycin E

General Information


DRACP ID  DRACP00782

Peptide Name   Ilamycin E

Sequence  XXLXAXX

Sequence Length  7

UniProt ID  Not available

PubChem CID  Not available

Origin  Streptomyces atratus SCSIO ZH25

Type  Native peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
HeLa Human papillomavirus-related endocervical adenocarcinoma Carcinoma IC50=3.9 µM MTT assay Not available 1
HepG2 Hepatoblastoma Blastoma IC50=4.9 µM MTT assay Not available 1
A549 Lung adenocarcinoma Carcinoma IC50=6.2 µM MTT assay Not available 1
CNE2 unknow Carcinoma IC50=14.9 µM MTT assay Not available 1
MCF-7 Invasive breast carcinoma of no special type Carcinoma IC50=3.9 µM MTT assay Not available 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  HL-7702 (L02): IC50=14.9 µM; HUVEC: IC50=18.6 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antibacterial



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Cyclic

Disulfide/Other Bond  NCB: X1<--->X7; SMB: X3<--->X4

N-terminal Modification  Free

C-terminal Modification  Free

Other Modification  X(1)=Pre-Trp; X(2)=(2S)-2-Aminohex-4-enoic acid; X(4)=METH-Leu; X(6)=N-Tyr; X(7)=METH-Leu

Chiral  L



Physicochemical Information


Formula  C9H8N2O-2

Absent amino acids  CDEFGHIKMNPQRSTVWY

Common amino acids  X

Mass  76938

Pl  6.11

Basic residues  0

Acidic residues  0

Hydrophobic residues  2

Net charge  0

Boman Index  673

Hydrophobicity  80

Aliphatic Index  70

Half Life 
  /

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  0

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 28855504

Title  Biosynthesis of ilamycins featuring unusual building blocks and engineered production of enhanced anti-tuberculosis agents

Doi  10.1038/s41467-017-00419-5

Year  2021

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.