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HlDFS1
General Information
DRACP ID DRACP00798
Peptide Name HlDFS1
Sequence GFGCPFNARRCHRHCRSIRRRAGYCAGRLRLTCTCVR
Sequence Length 37
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Undefined
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| A549 | Lung adenocarcinoma | Carcinoma | Not active up to 20 µM | Cell Viability Assay | 24h | 1 |
| K562 | Blast phase chronic myelogenous leukemia, BCR-ABL29 positive; Chronic myeloid leukemia | Leukemia | Not active up to 20 µM | Cell Viability Assay | 24h | 1 |
| THP-1 | Childhood acute monocytic leukemia; Acute monoblastic/monocytic leukemia | Leukemia | Not active up to 20 µM | Cell Viability Assay | 24h | 1 |
Hemolytic Activity Human erythrocytes: <5% Hemolysis=10µM; 18% Hemolysis=20µM; 60% Hemolysis=50µM
Normal (non-cancerous) Cytotoxicity HEK293T: Not active up to 20 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys4<--->Cys25; Cys11<--->Cys33; Cys15<--->Cys35
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C177H294N72O43S6
Absent amino acids DEKMQW
Common amino acids R
Mass 495340
Pl 11.9
Basic residues 12
Acidic residues 0
Hydrophobic residues 9
Net charge 12
Boman Index -13221
Hydrophobicity -52.16
Aliphatic Index 47.57
Half Life
Mammalian: 1.2 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 1865
Absorbance 280nm 51.81
Polar residues 15
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 28969703
Title Functional characterization of two defensins, HlDFS1 and HlDFS2, from the hard tick Haemaphysalis longicornis
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.