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Dermaseptin-PH
General Information
DRACP ID DRACP00800
Peptide Name Dermaseptin-PH
Sequence ALWKEVLKNAGKAALNEINNLVQ
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin Phyllomedusa hypochondrialis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=0.69µM | MTT assay | 24h | 1 |
| NCI-H157 | Lung squamous cell carcinoma | Carcinoma | IC50=2.01µM | MTT assay | 24h | 1 |
| U-251MG | Astrocytoma | Carcinoma | IC50=2.36µM | MTT assay | 24h | 1 |
| MDA-MB-435S | Amelanotic melanoma | Carcinoma | IC50=9.94µM | MTT assay | 24h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=11.8µM | MTT assay | 24h | 1 |
Hemolytic Activity Horse erythrocytes: 1% Hemolysis=16µM; 3% Hemolysis=64µM; 10% Hemolysis=128µM; 45% Hemolysis=256µM; 100% Hemolysis=512µM
Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=4.85µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C114H190N32O33
Absent amino acids CDFHMPRSTY
Common amino acids ALN
Mass 292958
Pl 9.44
Basic residues 3
Acidic residues 2
Hydrophobic residues 12
Net charge 1
Boman Index -1918
Hydrophobicity -9.57
Aliphatic Index 127.39
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 250
Polar residues 5
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29064402
Title Dermaseptin-PH: A Novel Peptide with Antimicrobial and Anticancer Activities from the Skin Secretion of the South American Orange-Legged Leaf Frog, Pithecopus (Phyllomedusa) hypochondrialis
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.