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Bombinin-BO1
General Information
DRACP ID DRACP00801
Peptide Name Bombinin-BO1
Sequence GIGSAILSAGKSIIKGLAKGLAEHF
Sequence Length 25
UniProt ID Not available
PubChem CID Not available
Origin Bombina orientalis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| SK-HEP-1 | Liver and intrahepatic bile duct epithelial neoplasm | Carcinoma | IC50=0.76µM | MTT assay | 6, 24, 48h | 1 |
| HepG2 | Hepatoblastoma | Blastoma | IC50=3.75µM | MTT assay | 6, 24, 48h | 1 |
| Huh-7 | Adult hepatocellular carcinoma; Adult hepatocellular carcinoma | Carcinoma | IC50=3.91µM | MTT assay | 6, 24, 48h | 1 |
Hemolytic Activity Human erythrocytes: 2.89% Hemolysis=26.3µM; Human erythrocytes=38.05% Hemolysis=52.5µM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C111H188N30O31
Absent amino acids CDMNPQRTVWY
Common amino acids G
Mass 286719
Pl 10.51
Basic residues 4
Acidic residues 1
Hydrophobic residues 12
Net charge 3
Boman Index 1104
Hydrophobicity 66.4
Aliphatic Index 125.2
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 8
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29098406
Title Molecular characterization and bioactivity evaluation of two novel bombinin peptides from the skin secretion of Oriental fire-bellied toad, Bombina orientalis
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.