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Bombinin-BO1
General Information
DRACP ID DRACP00802
Peptide Name Bombinin-BO1
Sequence GIGSAILSAGKSIIKGLAKGLA
Sequence Length 22
UniProt ID A0A219CMY0
PubChem CID Not available
Origin skin secretion of Oriental fire-bellied toad, Bombina orientalis
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| Hep-G2 | Hepatoblastoma; Hepatoblastoma | Blastoma | IC50=0.76 μM | MTT assay | 48h | 1 |
| SK-HEP-1 | Liver and intrahepatic bile duct epithelial neoplasm | Carcinoma | IC50=3.75 μM | MTT assay | 48h | 1 |
| Huh-7 | Adult hepatocellular carcinoma; Adult hepatocellular carcinoma | Carcinoma | IC50=3.91 μM | MTT assay | 48h | 1 |
Hemolytic Activity Human Red cells: only 2.89% hemolysis of the red cells at a concentration of 26.3 μM and 38.05% hemolysis at 52.5 μM
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C91H165N25O26
Absent amino acids CDEFHMNPQRTVWY
Common amino acids G
Mass 240025
Pl 11.1
Basic residues 3
Acidic residues 0
Hydrophobic residues 11
Net charge 3
Boman Index 1953
Hydrophobicity 93.18
Aliphatic Index 142.27
Half Life
Mammalian: 30 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 8
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29098406
Title Molecular characterization and bioactivity evaluation of two novel bombinin peptides from the skin secretion of Oriental fire-bellied toad, Bombina orientalis
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.