This work is licensed under a Creative Commons Attribution 4.0 International License.
PSN-PC
General Information
DRACP ID DRACP00804
Peptide Name PSN-PC
Sequence FLSLIPKIATGIAALAKHL
Sequence Length 19
UniProt ID Not available
PubChem CID Not available
Origin Phyllomedusa camba
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| NCI-H157 | Lung squamous cell carcinoma | Carcinoma | IC50=2.85µM | MTT assay | 24h | 1 |
Hemolytic Activity Horse erythrocytes: 100% Hemolysis=64µM; Horse erythrocytes=50% Hemolysis=23µM
Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=51.83µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C95H161N23O22
Absent amino acids CDEMNQRVWY
Common amino acids AL
Mass 229874
Pl 10.81
Basic residues 3
Acidic residues 0
Hydrophobic residues 12
Net charge 3
Boman Index 2387
Hydrophobicity 127.37
Aliphatic Index 164.74
Half Life
Mammalian: 20 hour
Yeast: 30 min
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29112170
Title PSN-PC: A Novel Antimicrobial and Anti-Biofilm Peptide from the Skin Secretion of Phyllomedusa-camba with Cytotoxicity on Human Lung Cancer Cell
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.