This work is licensed under a Creative Commons Attribution 4.0 International License.
Temporin-PE
General Information
DRACP ID DRACP00806
Peptide Name Temporin-PE
Sequence FLPIVAKLLSGLL
Sequence Length 13
UniProt ID A0A2H4WAJ8
PubChem CID Not available
Origin Pelophylax kl.esculentus(Europe edible frog)
Type Native peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| NCI-H157 | Lung squamous cell carcinoma | Carcinoma | IC50=34.56µM | MTT assay | Not available | 1 |
| U-251MG | Astrocytoma | Carcinoma | IC50=25.13µM | MTT assay | Not available | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=38.56µM | MTT assay | Not available | 1 |
| MDA-MB-435s | Amelanotic melanoma | Carcinoma | IC50=33.23µM | MTT assay | Not available | 1 |
Hemolytic Activity Horse erythrocytes(HD50=39.64μM)
Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=58.62µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antimicrobial; Antibacterial; Anitifungal
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Not available
C-terminal Modification Not available
Other Modification None
Chiral L
Physicochemical Information
Formula C69H118N14O15
Absent amino acids CDEHMNQRTWY
Common amino acids L
Mass 159802
Pl 9.7
Basic residues 1
Acidic residues 0
Hydrophobic residues 9
Net charge 1
Boman Index 3034
Hydrophobicity 196.92
Aliphatic Index 210
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 2
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29191658
Title Identification and target-modifications of temporin-PE: A novel antimicrobial peptide in the defensive skin secretions of the edible frog, Pelophylax kl. Esculentus
Doi 10.1016/j.bbrc.2017.11.173
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.