Peptide Libraray

Temporin-PE - Tat (48–57)

General Information

DRACP ID DRACP00807

Peptide Name Temporin-PE - Tat (48–57)

Sequence FLPIVAKLLSGLLGRKKRRQRRR

Sequence Length 23

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP Membrane-targeted

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
NCI-H157	Lung squamous cell carcinoma	Carcinoma	IC50=3.464µM	MTT assay	24h	1
U-251MG	Astrocytoma	Carcinoma	IC50=3.087µM	MTT assay	24h	1
PC-3	Prostate carcinoma	Carcinoma	IC50=3.051µM	MTT assay	24h	1
MDA-MB-435S	Amelanotic melanoma	Carcinoma	IC50=3.483µM	MTT assay	24h	1

Hemolytic Activity Horse erythrocytes: 50% Hemolysis=44.65µM

Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=9.976µM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antibacterial; Antifungal

Structure Information

PDB ID Not available

Predicted Structure DRACP00807

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C124H225N45O26

Absent amino acids CDEHMNTWY

Common amino acids R

Mass 315502

Pl 13.21

Basic residues 9

Acidic residues 0

Hydrophobic residues 9

Net charge 9

Boman Index -7488

Hydrophobicity -56.96

Aliphatic Index 118.7

Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 3

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 29191658

Title Identification and target-modifications of temporin-PE: A novel antimicrobial peptide in the defensive skin secretions of the edible frog, Pelophylax kl. Esculentus

Doi 10.1016/j.bbrc.2017.11.173

Year 2018

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available