This work is licensed under a Creative Commons Attribution 4.0 International License.
Lynronne-1
General Information
DRACP ID DRACP00810
Peptide Name Lynronne-1
Sequence LPRRNRWSKIWKKVVTVFS
Sequence Length 19
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | IC50=45.9µg/ml | Not available | Not available | 1 |
Hemolytic Activity Human erythrocytes: 20% Hemolysis=500µg/ml; Sheep erythrocytes: 10% Hemolysis=500µg/ml; Horse erythrocytes:0% Hemolysis=536µg/ml
Normal (non-cancerous) Cytotoxicity HUVEC: LC50=98.1µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C113H182N34O24
Absent amino acids ACDEGHMQY
Common amino acids KRV
Mass 272212
Pl 12.82
Basic residues 6
Acidic residues 0
Hydrophobic residues 8
Net charge 6
Boman Index -4782
Hydrophobicity -56.32
Aliphatic Index 86.84
Half Life
Mammalian: 3.5 hour
Yeast: 10 min
E.coli: >10 hour
Extinction Coefficient cystines 11000
Absorbance 280nm 611.11
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29214045
Title The rumen microbiome: an underexplored resource for novel antimicrobial discovery
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.