This work is licensed under a Creative Commons Attribution 4.0 International License.
Lynronne-3
General Information
DRACP ID DRACP00811
Peptide Name Lynronne-3
Sequence NRFTARFRRTPWRLCLQFRQ
Sequence Length 20
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| HepG2 | Hepatoblastoma | Blastoma | IC50=24.4µg/ml | Not available | Not available | 1 |
Hemolytic Activity Human erythrocytes: 45% Hemolysis=500µg/ml; Sheep erythrocytes: 0% Hemolysis=500µg/ml
Normal (non-cancerous) Cytotoxicity HUVEC: LC50>128µg/ml
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C119H186N42O26S
Absent amino acids DEGHIKMSVY
Common amino acids R
Mass 299217
Pl 12.8
Basic residues 6
Acidic residues 0
Hydrophobic residues 7
Net charge 6
Boman Index -8818
Hydrophobicity -105.5
Aliphatic Index 44
Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 5500
Absorbance 280nm 289.47
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29214045
Title The rumen microbiome: an underexplored resource for novel antimicrobial discovery
Year 2017
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.