This work is licensed under a Creative Commons Attribution 4.0 International License.
LL-37 fragment KR-12
General Information
DRACP ID DRACP00813
Peptide Name LL-37 fragment KR-12
Sequence KRIVQRIKDFLR
Sequence Length 12
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP Membrane-targeted
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| U-937/GTB | Adult acute monocytic leukemia; Acute monoblastic/monocytic leukemia | Leukemia | 15% Killing=100 µM | FDA cytotoxicity assay | 72h | 1 |
Hemolytic Activity Human erythrocytes: 50% Hemolysis>80 µM
Normal (non-cancerous) Cytotoxicity CEM-SS cells: 50% cell death >63.5 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antibacterial; Antifungal; Antiviral
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C71H126N24O16
Absent amino acids ACEGHMNPSTWY
Common amino acids R
Mass 176832
Pl 12.24
Basic residues 5
Acidic residues 1
Hydrophobic residues 5
Net charge 4
Boman Index -4834
Hydrophobicity -70.83
Aliphatic Index 121.67
Half Life
Mammalian: 1.1 hour
Yeast: 3 min
E.coli: 2 min
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 0
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 29430821
Title Alanine and Lysine Scans of the LL-37-Derived Peptide Fragment KR-12 Reveal Key Residues for Antimicrobial Activity
Year 2018
Literature 2
Pubmed ID 18591279
Title Anti-human immunodeficiency virus type 1 activities of antimicrobial peptides derived from human and bovine cathelicidins
Year 2008
Literature 3
Pubmed ID 32153522
Title Backbone Cyclization and Dimerization of LL-37-Derived Peptides Enhance Antimicrobial Activity and Proteolytic Stability
Year 2020
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.