Peptide Libraray

cMP-C

General Information

DRACP ID DRACP00815

Peptide Name cMP-C

Sequence CLNLKALLAVAKKILC

Sequence Length 16

UniProt ID Not available

PubChem CID Not available

Origin wasp venom

Type Native peptide

Classification

Active ACP Membrane-targeted

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
NCI-H157	Lung squamous cell carcinoma	Carcinoma	IC50=7.02 μM	MTT assay	24h	1
MDA-MB-435S	Amelanotic melanoma	Carcinoma	IC50=13.87 μM	MTT assay	24h	1
PC-3	Prostate carcinoma	Carcinoma	IC50=13.87 μM	MTT assay	24h	1
U-251MG	Astrocytoma	Carcinoma	IC50=8.56 μM	MTT assay	24h	1
MCF-7	Invasive breast carcinoma of no special type	Carcinoma	IC50=13.66 μM	MTT assay	24h	1

Hemolytic Activity Horse erythrocytes: HC50=40.11 μM

Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=57.15 μM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antitumor; Antimicrobial

Structure Information

PDB ID Not available

Predicted Structure DRACP00815

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C78H144N20O18S2

Absent amino acids DEFGHMPQRSTWY

Common amino acids L

Mass 198202

Pl 9.67

Basic residues 3

Acidic residues 0

Hydrophobic residues 10

Net charge 3

Boman Index 1826

Hydrophobicity 143.13

Aliphatic Index 183.13

Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 125

Absorbance 280nm 8.33

Polar residues 3

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 29904274

Title Evaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering

Doi 10.7150/ijbs.23419

Year 2018

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available