Peptide Libraray

MP-C

General Information

DRACP ID DRACP00816

Peptide Name MP-C

Sequence LNLKALLAVAKKIL

Sequence Length 14

UniProt ID Not available

PubChem CID Not available

Origin wasp venom

Type Native peptide

Classification

Active ACP Membrane-targeted

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
NCI-H157	Lung squamous cell carcinoma	Carcinoma	IC50=13.57 μM	MTT assay	24h	1
MDA-MB-435S	Amelanotic melanoma	Carcinoma	IC50=27.70 μM	MTT assay	24h	1
PC-3	Prostate carcinoma	Carcinoma	IC50=6.29 μM	MTT assay	24h	1
U-251MG	Astrocytoma	Carcinoma	IC50=36.65 μM	MTT assay	24h	1
MCF-7	Invasive breast carcinoma of no special type	Carcinoma	IC50=25.27 μM	MTT assay	24h	1

Hemolytic Activity Horse erythrocytes: HC50=40.11 μM

Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=57.15 μM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antitumor; Antimicrobial

Structure Information

PDB ID Not available

Predicted Structure DRACP00816

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C72H134N18O16

Absent amino acids CDEFGHMPQRSTWY

Common amino acids L

Mass 174006

Pl 11.1

Basic residues 3

Acidic residues 0

Hydrophobic residues 10

Net charge 3

Boman Index 1570

Hydrophobicity 127.86

Aliphatic Index 209.29

Half Life
Mammalian: 1.2 hour
Yeast: >20 hour
E.coli: >10 hour

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 1

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 29904274

Title Evaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering

Doi 10.7150/ijbs.23419

Year 2018

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available