Peptide Libraray

tMP-C

General Information

DRACP ID DRACP00817

Peptide Name tMP-C

Sequence RKKRRQRRRLNLKALLAVAKKIL

Sequence Length 23

UniProt ID Not available

PubChem CID Not available

Origin wasp venom

Type Native peptide

Classification

Active ACP Membrane-targeted

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
NCI-H157	Lung squamous cell carcinoma	Carcinoma	IC50=2.79 μM	MTT assay	24h	1
MDA-MB-435S	Amelanotic melanoma	Carcinoma	IC50=3.86 μM	MTT assay	24h	1
PC-3	Prostate carcinoma	Carcinoma	IC50=3.86 μM	MTT assay	24h	1
U-251MG	Astrocytoma	Carcinoma	IC50=3.36 μM	MTT assay	24h	1
MCF-7	Invasive breast carcinoma of no special type	Carcinoma	IC50=3.70 μM	MTT assay	24h	1

Hemolytic Activity Horse erythrocytes: HC50=77.94 μM

Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=9.18 μM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antitumor; Antimicrobial

Structure Information

PDB ID Not available

Predicted Structure DRACP00817

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Amidation

Other Modification None

Chiral L

Physicochemical Information

Formula C125H238N48O26

Absent amino acids CDEFGHMPSTWY

Common amino acids R

Mass 322217

Pl 13.21

Basic residues 11

Acidic residues 0

Hydrophobic residues 10

Net charge 11

Boman Index -9046

Hydrophobicity -88.7

Aliphatic Index 127.39

Half Life
Mammalian: 5.5 hour
Yeast: 3 min
E.coli: 2 min

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 1

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 29904274

Title Evaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering

Doi 10.7150/ijbs.23419

Year 2018

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available