[Phe]6 -Dec[Thr]11-Dec-NH2

General Information


DRACP ID  DRACP00821

Peptide Name   [Phe]6 -Dec[Thr]11-Dec-NH2

Sequence  SLLSLFRKLI

Sequence Length  10

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide (Derived from Decoralin)

Classification

  

Active ACP Membrane lysis



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
MCF-7 Invasive breast carcinoma of no special type Carcinoma IC50=50.0 µmol/L MTT assay 24h 1

Hemolytic Activity  Human red blood cells: MHC=12.50 μmol/L

Normal (non-cancerous) Cytotoxicity  Not available

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antitumor



Structure Information


PDB ID  Not available

Predicted Structure  DRACP00821

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Free

C-terminal Modification  Amidation

Other Modification  None

Chiral  L



Physicochemical Information


Formula  C57H100N14O13

Absent amino acids  ACDEGHMNPQTVWY

Common amino acids  L

Mass  135022

Pl  11.65

Basic residues  2

Acidic residues  0

Hydrophobic residues  6

Net charge  2

Boman Index  31

Hydrophobicity  125

Aliphatic Index  195

Half Life 
  Mammalian: 1.9 hour
  Yeast: >20 hour
  E.coli: >10 hour

Extinction Coefficient cystines  0

Absorbance 280nm  0

Polar residues  2

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30013694

Title  Natural and redesigned wasp venom peptides with selective antitumoral activity

Doi 10.3762/bjoc.14.144

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.