This work is licensed under a Creative Commons Attribution 4.0 International License.
[Leu]11 -Dec-NH2
General Information
DRACP ID DRACP00825
Peptide Name [Leu]11 -Dec-NH2
Sequence SLLSLIRKLLT
Sequence Length 11
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide (Derived from Decoralin)
Classification
Active ACP Membrane lysis
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| MCF-7 | Invasive breast carcinoma of no special type | Carcinoma | IC50=12.5 µmol/L | MTT assay | 24h | 1 |
Hemolytic Activity Human red blood cells: MHC=25.00 μmol/L
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Amidation
Other Modification None
Chiral L
Physicochemical Information
Formula C58H109N15O15
Absent amino acids ACDEFGHMNPQVWY
Common amino acids L
Mass 143515
Pl 11.65
Basic residues 2
Acidic residues 0
Hydrophobic residues 6
Net charge 2
Boman Index -32
Hydrophobicity 116.36
Aliphatic Index 212.73
Half Life
Mammalian: 1.9 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 0
Absorbance 280nm 0
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30013694
Title Natural and redesigned wasp venom peptides with selective antitumoral activity
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.