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L10, 11-DPS3
General Information
DRACP ID DRACP00829
Peptide Name L10, 11-DPS3
Sequence ALWKDILKNLLKAALNEINQIVQ
Sequence Length 23
UniProt ID Not available
PubChem CID Not available
Origin skin secretion of Phyllomedusa sauvagii
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| NCI-H157 | Lung squamous cell carcinoma | Carcinoma | IC50=0.12 μM | MTT assay | 24h | 1 |
| PC-3 | Prostate carcinoma | Carcinoma | IC50=1.85 μM | MTT assay | 24h | 1 |
Hemolytic Activity Horse blood cells: HC50=3.44 μM
Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=8.76 μM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor; Antimicrobial
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C122H206N32O33
Absent amino acids CFGHMPRSTY
Common amino acids L
Mass 304181
Pl 9.44
Basic residues 3
Acidic residues 2
Hydrophobic residues 13
Net charge 1
Boman Index -1202
Hydrophobicity 21.74
Aliphatic Index 161.3
Half Life
Mammalian: 4.4 hour
Yeast: >20 hour
E.coli: >10 hour
Extinction Coefficient cystines 5500
Absorbance 280nm 250
Polar residues 3
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30087268
Title Biological Activities of Cationicity-Enhanced and Hydrophobicity-Optimized Analogues of an Antimicrobial Peptide, Dermaseptin-PS3, from the Skin Secretion of Phyllomedusa sauvagii
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.