Peptide Libraray

LP-61

General Information

DRACP ID DRACP00831

Peptide Name LP-61

Sequence IEELIKKSEEQQKKNEEELKKLEX

Sequence Length 24

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
TZM-bl	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	50% Cytotoxicity=193.63±13.92 µM	CellTiter 96 AQueous One Solution assay	48h	1
MT-4	Human acute lymphoblastic leukemia cell line	Leukemia	50% Cytotoxicity=164.47±37.69µM	CellTiter 96 AQueous One Solution assay	48h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity HEK293T: 50% Cytotoxicity=140.43±10.7 µM; PBMC: 50% Cytotoxicity=46.43±2.6 µM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antiviral

Structure Information

PDB ID Not available

Predicted Structure Not available

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Acetylation

C-terminal Modification Amidation

Other Modification X(24)= Lysine with palmitoylated side group

Chiral L

Physicochemical Information

Formula C123H210N32O43

Absent amino acids ACDFGHMPRTVWY

Common amino acids E

Mass 334563

Pl 4.6

Basic residues 6

Acidic residues 8

Hydrophobic residues 5

Net charge -2

Boman Index -8430

Hydrophobicity -176.25

Aliphatic Index 81.25

Half Life
/

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 2

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 30089693

Title Structural and Functional Characterization of Membrane Fusion Inhibitors with Extremely Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus

Doi 10.1128/JVI.01088-18

Year 2018

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available