LP-52

General Information


DRACP ID  DRACP00834

Peptide Name   LP-52

Sequence  WEQKIEELLKKAEEQQKKNEEELKKLEX

Sequence Length  28

UniProt ID  Not available

PubChem CID  Not available

Origin  Synthetic

Type  Synthetic peptide

Classification

  

Active ACP



Activity Information


Cell Line Disease Cancer Classified Activity Assay Testing Time Literature
TZM-bl Human papillomavirus-related endocervical adenocarcinoma Carcinoma 50% Cytotoxicity=112.9±2.21µM CellTiter 96 AQueous One Solution assay 48h 1
MT-4 Human acute lymphoblastic leukemia cell line Leukemia 50% Cytotoxicity=94.06±4.97µM CellTiter 96 AQueous One Solution assay 48h 1

Hemolytic Activity  Not available

Normal (non-cancerous) Cytotoxicity  HEK293T cells: 50% Cytotoxicity=88.86±6.68 µM; PBMC: 50% Cytotoxicity=114.8±12.68 µM

Target  Not available

Affinity  Not available

Mechanism  Not available

Nature  Anticancer; Antiviral



Structure Information


PDB ID  Not available

Predicted Structure  Not available

Helicity  Not available

Linear/Cyclic  Linear

Disulfide/Other Bond  Not available

N-terminal Modification  Acetylation

C-terminal Modification  Amidation

Other Modification  X(28)= Lysine with palmitoylated side group

Chiral  L



Physicochemical Information


Formula  C150H247N39O49

Absent amino acids  CDFGHMPRSTVY

Common amino acids  E

Mass  397262

Pl  4.67

Basic residues  7

Acidic residues  9

Hydrophobic residues  7

Net charge  -2

Boman Index  -9466

Hydrophobicity  -186.43

Aliphatic Index  73.21

Half Life 
  /

Extinction Coefficient cystines  5500

Absorbance 280nm  203.7

Polar residues  1

Amino acid distribution



Literature Information


Literature 1

Pubmed ID 30089693

Title  Structural and Functional Characterization of Membrane Fusion Inhibitors with Extremely Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus

Doi 10.1128/JVI.01088-18

Year  2018

Patent

Patent ID Not available

Patent Title  Not available

Other Iinformation  Not available

Other Published ID  Not available




DRACP is developed by Dr.Zheng's team.