This work is licensed under a Creative Commons Attribution 4.0 International License.
LP-80
General Information
DRACP ID DRACP00835
Peptide Name LP-80
Sequence WEQKIEELLKKAEEQQKKNEEELKKLEX
Sequence Length 28
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Synthetic peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| TZM-bl | Human papillomavirus-related endocervical adenocarcinoma | Carcinoma | 50% Cytotoxicity=62.33µM | CellTiter 96 AQueous One Solution assay | 48h | 1 |
| MT-4 | Human acute lymphoblastic leukemia cell line | Leukemia | 50% Cytotoxicity=218.37µM | CellTiter 96 AQueous One Solution assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity HEK293T cells: 50% Cytotoxicity=72.23 µM; PBMC: 50% Cytotoxicity=37.37 µM
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antiviral
Structure Information
Helicity Not available
Linear/Cyclic Linear
Disulfide/Other Bond Not available
N-terminal Modification Acetylation
C-terminal Modification Amidation
Other Modification X(28)=Lysine with oleoylated side group
Chiral L
Physicochemical Information
Formula C150H247N39O49
Absent amino acids CDFGHMPRSTVY
Common amino acids E
Mass 397262
Pl 4.67
Basic residues 7
Acidic residues 9
Hydrophobic residues 7
Net charge -2
Boman Index -9466
Hydrophobicity -186.43
Aliphatic Index 73.21
Half Life
/
Extinction Coefficient cystines 5500
Absorbance 280nm 203.7
Polar residues 1
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30089693
Title Structural and Functional Characterization of Membrane Fusion Inhibitors with Extremely Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.