Peptide Libraray

LP-50

General Information

DRACP ID DRACP00836

Peptide Name LP-50

Sequence YTSLIEELIKKSEEQQKKNEEELKKLEX

Sequence Length 28

UniProt ID Not available

PubChem CID Not available

Origin Synthetic

Type Synthetic peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
TZM-bl	Human papillomavirus-related endocervical adenocarcinoma	Carcinoma	50% Cytotoxicity=106.4±2.72µM	CellTiter 96 AQueous One Solution assay	48h	1
MT-4	Human acute lymphoblastic leukemia cell line	Leukemia	50% Cytotoxicity=138.37±6.55µM	CellTiter 96 AQueous One Solution assay	48h	1

Hemolytic Activity Not available

Normal (non-cancerous) Cytotoxicity HEK293T cells: 50% Cytotoxicity=408±40.1 µM; PBMC: 50% Cytotoxicity=212.6±25.71 µM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antiviral

Structure Information

PDB ID Not available

Predicted Structure Not available

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Acetylation

C-terminal Modification Amidation

Other Modification X(28)= Lysine with palmitoylated side group

Chiral L

Physicochemical Information

Formula C145H242N36O50

Absent amino acids ACDFGHMPRVW

Common amino acids E

Mass 388149

Pl 4.6

Basic residues 6

Acidic residues 8

Hydrophobic residues 6

Net charge -2

Boman Index -8549

Hydrophobicity -147.5

Aliphatic Index 83.57

Half Life
/

Extinction Coefficient cystines 1490

Absorbance 280nm 55.19

Polar residues 5

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 30089693

Title Structural and Functional Characterization of Membrane Fusion Inhibitors with Extremely Potent Activity against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus

Doi 10.1128/JVI.01088-18

Year 2018

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available