This work is licensed under a Creative Commons Attribution 4.0 International License.
VGB
General Information
DRACP ID DRACP00838
Peptide Name VGB
Sequence CIKPHQGQHICNDE
Sequence Length 14
UniProt ID Not available
PubChem CID Not available
Origin Synthetic
Type Native peptide
Classification
Active ACP
Activity Information
| Cell Line | Disease | Cancer Classified | Activity | Assay | Testing Time | Literature |
|---|---|---|---|---|---|---|
| 4T1 | Malignant neoplasms of the mouse mammary gland | Carcinoma | IC50=0.61 μM | MTT assay | 48h | 1 |
| U-87MG ATCC | Glioblastoma | Blastoma | IC50=0.92 μM | MTT assay | 48h | 1 |
Hemolytic Activity Not available
Normal (non-cancerous) Cytotoxicity Not available
Target Not available
Affinity Not available
Mechanism Not available
Nature Anticancer; Antitumor
Structure Information
Helicity Not available
Linear/Cyclic Cyclic
Disulfide/Other Bond Cys1<--->Cys11
N-terminal Modification Free
C-terminal Modification Free
Other Modification None
Chiral L
Physicochemical Information
Formula C66H104N22O22S2
Absent amino acids AFLMRSTVWY
Common amino acids CHIQ
Mass 185389
Pl 6.48
Basic residues 3
Acidic residues 2
Hydrophobic residues 2
Net charge 1
Boman Index -3478
Hydrophobicity -112.86
Aliphatic Index 55.71
Half Life
Mammalian: 2.8 hour
Yeast: 10 min
E.coli: 2 min
Extinction Coefficient cystines 125
Absorbance 280nm 9.62
Polar residues 4
Amino acid distribution
Literature Information
Literature 1
Pubmed ID 30251659
Title Dual blockade of VEGFR1 and VEGFR2 by a novel peptide abrogates VEGF-driven angiogenesis, tumor growth, and metastasis through PI3K/AKT and MAPK/ERK1/2 pathway
Doi 10.1016/j.bbagen.2018.08.013
Year 2018
Patent
Patent ID Not available
Patent Title Not available
Other Iinformation Not available
Other Published ID Not available
This work is licensed under a Creative Commons Attribution 4.0 International License.