Peptide Libraray

R2PLx-22

General Information

DRACP ID DRACP00840

Peptide Name R2PLx-22

Sequence GIMDTVKNAAKNLAGQLLDKLK

Sequence Length 23

UniProt ID Not available

PubChem CID Not available

Origin skin secretions of the pickerel frog (Rana palustris)

Type Native peptide

Classification

Active ACP

Activity Information

Cell Line	Disease	Cancer Classified	Activity	Assay	Testing Time	Literature
NCI-H157	Lung squamous cell carcinoma	Carcinoma	IC50=843.40 μM	MTT assay	24h	1
MDA-MB-435S	Amelanotic melanoma	Carcinoma	IC50=872.70 μM	MTT assay	24h	1
PC-3	Prostate carcinoma	Carcinoma	IC50=283.90 μM	MTT assay	24h	1
U-251MG	Astrocytoma	Carcinoma	IC50=104.10 μM	MTT assay	24h	1
MCF-7	Invasive breast carcinoma of no special type	Carcinoma	IC50=109.30 μM	MTT assay	24h	1

Hemolytic Activity Horse erythrocytes: Low haemolytic activity

Normal (non-cancerous) Cytotoxicity HMEC-1: IC50=588.20 μM

Target Not available

Affinity Not available

Mechanism Not available

Nature Anticancer; Antimicrobial

Structure Information

PDB ID Not available

Predicted Structure Not available

Helicity Not available

Linear/Cyclic Linear

Disulfide/Other Bond Not available

N-terminal Modification Free

C-terminal Modification Free

Other Modification None

Chiral Mix

Physicochemical Information

Formula C102H179N29O30S

Absent amino acids CEFHPRSWY

Common amino acids KL

Mass 271641

Pl 10.33

Basic residues 4

Acidic residues 2

Hydrophobic residues 9

Net charge 2

Boman Index -2273

Hydrophobicity -14.78

Aliphatic Index 110.43

Half Life
/

Extinction Coefficient cystines 0

Absorbance 280nm 0

Polar residues 5

Amino acid distribution

Literature Information

Literature 1

Pubmed ID 30279210

Title A novel antimicrobial peptide, Ranatuerin-2PLx, showing therapeutic potential in inhibiting proliferation of cancer cells

Doi 10.1042/BSR20180710

Year 2018

Patent

Patent ID Not available

Patent Title Not available

Other Iinformation Not available

Other Published ID Not available